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The **pituitary gland**, also known as the hypophysis or "master gland," is located at the base of the brain within the sella turcica, a depression in the sphenoid bone. It is connected to the hypothalamus by a stalk called the pituitary stalk (or infundibulum). The pituitary gland has two distinct regions, the anterior and posterior pituitary, which together secrete nine different peptide or protein hormones. The anterior pituitary is regulated by releasing or release-inhibiting hormones produced by the hypothalamus, while the posterior pituitary releases hormones in response to signals from neurosecretory cells in the hypothalamus. The posterior lobe contains axons from these hypothalamic neurons. *LICENSES AND ATTRIBUTIONS CC licensed content, Shared previously, Endocrine System, Authored by: OpenStax College. License: CC BY: Attribution. License Terms: Download for free at http://cnx.org/contents/FkktNELv@3/Endocrine-System*